Thursday, June 21, 2012

More on the Safety of Cry1Ab

HT: David Tribe

Excerpted from:

Alain de Weck *
* Emeritus Professor of Immunology, Institute of Immunology (University of Bern,
Switzerland), Department of Allergology (University of Navarra, Spain)

"In summary (25), Cry1Ab has no characteristics associated with toxins or food allergens, it has no peptide sequence homology with known allergens (26), it has no N-glycosylation sites for a secondary immunization, it is rapidly degraded by gastric and intestinal fluids, it has no side effects in mice force-fed orally at a dose of 5 g / kg. So there is a reasonable certainty and there is no documented adverse effects of the inclusion of Cry1Ab in the feed and food (25). In this context, the first actual assertion of such an absorption in humans  represent or actually the first one and should have made the Canadian authors particularly cautious, but this is clearly not the case."

(25) Xu W, Cao S, He X, Luo Y, Guo X, Yuan Y, Huang K Safety assessment of Cry1Ab/Ac fusion protein. Food Chem Toxicol. 2009; 47: 1459-65.

(26) Randhawa GJ, Singh M, Grover M. Bioinformatic analysis for allergenicity assessment of Bacillus thuringiensis Cry proteins expressed in insect-resistant food crops. Food Chem Toxicol. 2011; 49 ; 356-62.

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